Polynucleotide Strong (2.5%)

Polynucleotide Strong is a higher-concentration injectable treatment designed to deliver deeper skin regeneration. It targets more pronounced fine lines, wrinkles and loss of firmness, stimulating collagen production and supporting the skin’s natural repair process for a smoother, more resilient complexion.

At a concentration of 2.5%, this is the most advanced formulation in the polynucleotide range. It is particularly well-suited to those looking for a more intensive result or who have not achieved their goals with a standard polynucleotide treatment.

Book Treatment

Book Consultation

Treatment areas: Face, jawline, scalp

SUITABLE FOR

Deeper wrinkles, loss of firmness and skin laxity

TREATMENT TIME

30 mins

FIRST RESULTS

1 to 2 weeks

DOWNTIME

Minimal

LONGEVITY

Up to 6 months

What to Expect

Your treatment begins with a personalised consultation where your doctor will assess your skin, discuss your concerns and confirm whether Polynucleotide Strong is the right option for you. It is suitable for most adults, with the exception of those who are pregnant, breastfeeding or have a known shellfish allergy. If you have previously tried a standard polynucleotide treatment, your doctor will take this into account when planning your approach.

Treatment involves a series of small injections placed in targeted areas of the face or scalp. Each session takes around 30 minutes and involves minimal disruption to your day. Two sessions spaced four weeks apart are typically recommended for the best outcome. Mild redness or swelling may occur after treatment but usually resolves within 24 hours. Results develop gradually and continue to improve following the second session.

DEEP REGENERATION

Higher strength for more intensive skin renewal

DOCTOR-LED CARE

Every treatment starts with a full assessment.

QUICK TREATMENT

Around 30 minutes with minimal downtime.

ALL SKIN TYPES

Works well across a range of skin concerns and complexions

Prices

€£

From €250

Doctor / Senior Doctor & Consultant
From €250 / €275

All Pricing

All pricing is available here.

Treatment Price List

Before and After Polynucleotide Strong

Check out some of our incredible Polynucleotide Strong results below.

SMOOTHER SKIN TEXTURE

Refines and improves overall skin texture for a more polished, even complexion

FEWER LINES AND WRINKLES

Reduces the visibility of deeper lines, giving the face a more rested, youthful look.

FIRMER, STRONGER SKIN

Promotes natural collagen production to restore elasticity and improve skin resilience

Benefits of Polynucleotide Strong

Polynucleotide Strong works by delivering a higher concentration of purified polynucleotides directly into the skin, where they trigger the body’s natural regenerative response. This stimulates the production of collagen, elastin and hyaluronic acid, improving the skin’s structure, firmness and hydration from within.

It is a particularly good option for those with more visible signs of ageing, or for anyone seeking a more intensive treatment following standard polynucleotide sessions. Results build progressively over the weeks following treatment, giving a natural-looking improvement in skin quality that lasts up to six months.

Post-Treatment Care & Side Effects

A small amount of care in the first 24 to 48 hours helps protect the treatment and support the best possible outcome. Your doctor will go through this with you before you leave.

Avoid applying makeup for at least 24 hours
Avoid vigorous exercise for 48 hours
Do not massage or rub the treated area
Avoid excessive heat, including saunas and steam rooms
Keep the area clean and avoid pressure on injection sites

If you have any concerns after treatment, your clinic team is always on hand to help.

Polynucleotide Strong is well tolerated by most patients. Side effects are generally mild and short-lived.
Common temporary side effects include:

Redness at or around the injection sites
Mild swelling in the treated area
Light bruising

These are a normal response to the injection process and typically resolve within a few days. Your doctor will discuss all potential side effects in full during your consultation.

Polynucleotides Results Timeline

Immediately after treatment:
Some redness or mild swelling may be present. This is expected and settles quickly.
Days 1 to 3:
Initial swelling resolves. Skin may begin to feel more hydrated and refreshed.
Weeks 1 to 2:
The full effects of the first session become visible. Skin appears smoother, with improved tone and texture.
After your second session (around week 6):
Collagen production continues to build. Deeper lines appear softer, and skin feels noticeably firmer and more resilient.
Up to 6 months:
Results are maintained with ongoing improvement in skin quality. A follow-up treatment at this stage helps sustain the outcome.

Polynucleotide Strong delivers results that develop at the skin’s own pace, improving progressively rather than all at once. Most patients find the gradual, natural-looking change is exactly what they were looking for.

Polynucleotide Strong FAQs

What is Polynucleotide Strong (2.5%)?

Polynucleotide Strong (2.5%), an advanced skincare treatment, is intended to significantly improve skin texture, reduce fine lines and wrinkles, and stimulate collagen production for a rejuvenated appearance.

How Many Treatments Do You Need?

We advise two to three sessions. The initial sessions might be scheduled three to four weeks apart. To retain the greatest results we recommend a maintenance treatment every 6-9 months. After just two treatments, you should expect to see an average 23% reduction in wrinkles. The procedure aims to minimise fine lines and wrinkles, replenish dry skin, and improve circulation.

How Does Polynucleotide Differ From Profhilo

When compared to Profhilo®, which relies on hyaluronic acid, Polynucleotides stand out as a polynucleotide bio-stimulant. It’s vital to remember that neither one is better than the other; rather, they each have unique compositions and produce various outcomes. Polynucleotide are recommended to treat sagging and dry skin, while Profhilo® shines as a powerful hydration treatment.

What can I expect during the treatment session?

Each session typically lasts about 30 minutes, during which the product is applied to targeted areas to maximise skin rejuvenation.

What is the Difference Between Polynucleotide and Polynucleotide Strong?

The main difference between Polynucleotide Strong (2.5%) and regular Polynucleotide Rejuvenation is the concentration of active ingredients. The Strong (2.5%) version has a higher concentration, making it more potent and targeted for greater skin rejuvenation results. This makes it especially effective for deeper wrinkles and more visible signs of ageing, resulting in a more intensive treatment than the regular version.

Treatments

All Polynucleotide Treatments

Explore our full range of PDRN skin regeneration treatments.

Polynucleotides Eyes

Targets fine lines, puffiness and dark circles in the delicate periorbital area.

Polynucleotides Rejuvenation (2%)

Full-face renewal improving texture, tone and deep hydration with a 2% concentration.

Polynucleotides Strong (2.5%)

Higher concentration formula for advanced lifting, laxity and deeper tissue repair.

Patient Experiences

What Our Patients Say

Cork

"Dr. Chrisna is amazing. To me, she is the best in Cork — her skills, knowledge, great sense of aesthetics but also very strong ethics are incredible. She even fixed issues I had post a treatment at another place. I don't know any better doctor in Cork. Highly recommended."

Cork

"Came today for my 2-week check-up on a gummy smile procedure. The ladies here are so kind and professional. I wasn't pushed to get anything extra. It is such a clean, tidy and organised practice and the waiting room is fab!"

Cork

"First timer and I do not know why I waited so long. Lovely clinic with amazing and friendly staff. Spotless and a great vibe! Thanks Dr. Ciara."

Cork

"A 5-star experience. The clinic was very welcoming and staff were very friendly. It was my first time having my lips done. They went through what to expect in great detail. At 50 I only wanted a very natural result — this was exactly what I came away with. Extremely happy."

Cork

"Beautiful spotless clean modern clinic. Friendly professional staff. Very informative consultation before my treatment with Dr Emma. Extremely happy with my treatment."

Cork

"I got veins removed from under my eyes using the Halo V laser. Lauren explained everything while she was doing it and it went so smoothly. The results were absolutely amazing after just one treatment. I'm absolutely thrilled with how fast it worked."

Dublin

"The most welcoming clinic and without a doubt the best in my experience. The honesty and genuine care was on another level. So happy with the results. You have a customer for life. Thank you."

Dublin

"I got the smallest 0.5ml filler and, oh my god, I'm addicted. My lips look so natural and amazing. Don't be scared the first day as they will be swollen, but once settled they look so amazing. The doctors are so skilled and professional — this clinic has me captive now!"

Dublin

"I had a really positive experience with Dr Meg. She was incredibly attentive, took the time to listen to what I wanted, and offered thoughtful, expert advice. I felt completely at ease and never rushed. I would definitely recommend her to anyone considering treatment."

Dublin

"Dr. Agatha took her time to understand the outcome I wanted. I took her advice and trusted her. I've never been happier with filler results — she kept the shape and evened out exactly what was needed. Thank you!"

Dublin

"Wonderful experience, really efficient and professional. Didn't feel a thing, the girl was so friendly and welcoming. Highly recommend."

Limerick

"Thank you very much for your help in correcting my face. I am so happy. The girls in Eden are very nice, they always explain everything clearly. I highly recommend Eden and all the girls who work there."

Limerick

"Great service. I had laser treatment with Laura, she was very professional and friendly, put me at ease straight away and explained the whole procedure thoroughly."

Limerick

"Wonderful experience with Dr. Clare, love visiting Eden — staff are always so friendly and very helpful. Mairead was so kind, informative and very friendly also."

Limerick

"I have had a few treatments at Eden Medical. The staff are absolutely lovely, very warm and welcoming from the moment you arrive. I would highly recommend Eden Medical Limerick."

Limerick

"I had a lovely experience with Dr. Claire this week. She was very professional and took great care with me. I hardly felt a thing. As always Mairead greeted me with such a lovely welcoming manner. Book immediately — you will not regret it. 10/10."

Galway

"Had such a positive experience at Eden Medical. The staff are very friendly and accommodating. I visited Dr. Miriam who answered all my questions, put me at ease and was very thorough. Delighted with my results and will definitely be visiting again!"

Galway

"Really lovely clinic and the staff were kind, helpful and thorough! I felt confident that I was in good hands and was at ease throughout the treatment."

Galway

"My first time getting lip filler and I was a bit nervous. Dr Méabh was so kind, patient and professional — I sailed through the procedure and was delighted with the results. Cannot recommend this place enough!"

Galway

"Always a lovely experience in Eden. I highly recommend Dr. Maebh and Dr. Miriam — both are fantastic doctors."

Galway

"I've had the Traptox treatment with Dr. Méabh twice to treat chronic trapezius/neck pain. She is a highly skilled professional who shows genuine interest in her patient's needs. The clinic is spacious, spotless and the receptionist is very kind and efficient."